國家“傑出青年科學基金”獲得者
中國科學院生物物理研究所，表觀遺傳調控與幹預全國重點實驗室
，研究組長
，博士生導師
中國科學院大學

，崗位教授

研究方向

蛋白質-RNA複合物在轉錄和表觀遺傳層麵如何調控基因表達，以及如何在細胞分化和癌症發生等命運決定過程中發揮作用。主要研究內容包括：

1、  RNA結合蛋白的轉錄調控機製；

2、  反向RNA的功能與作用機製研究；

3、  RNA-Protein研究的新技術開發。

 

學術成就

2010年於武漢大學獲博士學位，2010年至2015在美國加州大學聖地亞哥分校進行博士後研究工作。主要從事RNA結合蛋白和非編碼RNA在細胞重編程、幹細胞分化及癌症發生過程中的功能機製研究。近年來主要圍繞RNA結合蛋白和microRNA (miRNA)在神經細胞重編程
、癌症發生和幹細胞分化等方麵的作用開展了係統性探索, 取得了前沿性突破,在Nature
、Cell、Mol Cell、Nat Cell Biol等頂刊發表數十篇科研論文。

 

代表論文

1. Liang Liang^#, Changchang Cao^#, Lei Ji^#, Zhaokui Cai^#, Di Wang, Rong Ye, Juan Chen, Xiaohua Yu, Jie Zhou, Zhibo Bai, Ruoyan Wang, Xianguang Yang, Ping Zhu, Yuanchao Xue*. Complementary Alu sequences mediate enhancer-promoter selectivity. Nature. 2023; 619(7971):868-875. (Highlight by Nature Reviews Genetics, 2023, 24: 588; Mol Cell, 2023; 83(18): 3234-3235)

2. Hailian Zhao^#, Zhaokui Cai^#, Jian Rao^#, Di Wu^#, Lei Ji, Rong Ye, Di Wang, Juan Chen, Changchang Cao, Naijing Hu, Ting Shu, Ping Zhu, Jianwei Wang*, Xi Zhou*, Yuanchao Xue*. SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis. Mol Cell. 2023: S1097-2765(23)00978-4. (Featured Article; Cover story)

3. Rong Ye^#, Naijing Hu^#, Changchang Cao, Ruibao Su, Shihan Xu, Chen Yang, Xiangtian Zhou, Yuanchao Xue*. Capture RIC-seq reveals positional rules of PTBP1-associated RNA loops in splicing regulation. Mol Cell. 2023; 83(8): 1311- 1327.e7. (Featured Article; Preview by Mol Cell, 2023, 83(8): 1206-1207)

4. Jing Guo^#, Hailian Zhao^#, Jue Zhang^#, Xiangjiang Lv, Shen Zhang, Ruibao Su, Wei Zheng, Jing Dai, Fei Meng, Fei Gong, Guangxiu Lu, Yuanchao Xue*, Ge Lin*. Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition. Adv Sci. 2023; e2205500.

5. Hui Li, Hailian Zhao, Chunhui Yang, Ruibao Su, Min Long, Jinliang Liu, Lanying Shi, Yuanchao Xue*, You-Qiang Su*. LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice. Adv Sci. 2023; 10(18):e2300043.

6. Yigan Zhang^#, Jinyue Zhang^#, Yuanchao Xue*. ADAR1: a mast regulator of aging and immunity. Signal Transduct Target Ther. 2023; 8(1):7.

7. Rong Ye^#, Naijing Hu^#, Yuanchao Xue*. CRIC-seq protocol for in situ profiling of proximal RNA-RNA contacts associated with RNA-binding proteins. STAR Protoc. 2023; 4(3):102401.

8. Jianzhong Su^#, *, Jian Yuan^#, Liangde Xu^#, Shilai Xing^#, Mengru Sun^#, Yinghao Yao, Yunlong Ma, Fukun Chen, Longda Jiang, Kai Li, Xiangyi Yu, Zhengbo Xue, Yaru Zhang, Dandan Fan, Ji Zhang, Hui Liu, Xinting Liu, Guosi Zhang, Hong Wang, Meng Zhou, Fan Lyu, Gang An, Xiaoguang Yu; Myopia Associated Genetics and Intervention Consortium; Yuanchao Xue*, Jian Yang*, Jia Qu*. Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population. Cell Rep. 2023; 42(5):112510.

9. Peng Wang^#, Qiushi Wang^#, Lianwan Chen^#, Zheng Cao^#, Hailian Zhao, Ruibao Su, Ning Wang, Xiaojing Ma, Jin Shan, Xinyan Chen, Qi Zhang, Baochen Du, Zhiheng Yuan, Yanmei Zhao*, Xiaorong Zhang*, Xuejiang Guo*, Yuanchao Xue*, Long Miao*. RNA-binding protein complex AMG-1/SLRP-1 mediates germline development and spermatogenesis by maintaining mitochondrial homeostasis in Caenorhabditis elegans. Sci Bull. 2023; 68(13):1399-1412.

10. Yue Lv^#, Gang Lu^#, Yuling Cai^#, Ruibao Su^#, Liang Liang, Xin Wang, Wenyu Mu, Xiuqing He, Tao Huang, Jinlong Ma, Yueran Zhao, Zi-Jiang Chen*, Yuanchao Xue*, Hongbin Liu*, Wai-Yee Chan*. RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits. Protein Cell. 2022; 14(1):51-63.

11.Yuanchao Xue*. Architecture of RNA-RNA interactions. Curr Opin Genet Dev. 2022; 72:138-144.

12. Di Wang^#, Rong Ye^#, Zhaokui Cai, Yuanchao Xue*. Emerging roles of RNA-RNA interactions in transcriptional regulation (Invited review). WIRES RNA. 2022; 18:e1712.

13. Changchang Cao^#, Zhaokui Cai^#, Xia Xiao^#, Jian Rao, Juan Chen, Naijing Hu, Minnan Yang, Xiaorui Xing, Yongle Wang, Manman Li, Bing Zhou, Xiangxi Wang, Jianwei Wang*, Yuanchao Xue*. The architecture of the SARS-CoV-2 RNA genome inside virion. Nat Commun. 2021; 12(1): 3917. (Best of BMB in 2021)

14. Changchang Cao^#, Zhaokui Cai^#, Rong Ye, Ruibao Su, Naijing Hu, Hailian Zhao, Yuanchao Xue*. Global in situ profiling of RNA-RNA spatial interactions with RIC-seq. Nat Protoc. 2021; 16(6): 2916-2946.

15. Ruibao Su^#, Li-Hua Fan^#, Changchang Cao^#, Lei Wang, Zongchang Du, Zhaokui Cai, Ying-Chun Ouyang, Yue Wang, Qian Zhou, Ligang Wu, Nan Zhang, Xiaoxiao Zhu, Wen-Long Lei, Hailian Zhao, Yong Tian, Shunmin He, Catherine C L Wong*, Qing-Yuan Sun*, Yuanchao Xue*. Global profiling of RNA-binding protein target sites by LACE-seq. Nat Cell Biol. 2021; 23(6): 664-675.

16. Zhaokui Cai^#, Changchang Cao^#, Lei Ji^#, Rong Ye, Di Wang, Cong Xia, Sui Wang,  Zongchang Du, Naijing Hu, Xiaohua Yu, Juan Chen, Lei Wang, Xianguang Yang, Shunmin He, Yuanchao Xue*. RIC-seq for global in situ profiling of RNA-RNA spatial interactions. Nature. 2020; 582, 432-437. (Highlight by Nature Methods, 2020, 17, 760; Recommended in Faculty Opinions)

17. Juan Chen^#, Zhaokui Cai^#, Meizhu Bai^#, Xiaohua Yu^#, Chao Zhang^#, Changchang Cao, Xihao Hu, Lei Wang, Ruibao Su, Di Wang, Lei Wang, Yingpeng Yao, Rong Ye, Baidong Hou, Yang Yu, Shuyang Yu, Jinsong Li, Yuanchao Xue*. The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. Cell Res. 2018; 28: 981-995. (Cover story; highlight by Cell Res, 2018 (10): 963-964)

18. Jinyang Zhang^#, Lingling Hou^#, Zhenqiang Zuo^#, Peifeng Ji, Xiaorong Zhang, Yuanchao Xue, Fangqing Zhao*. Comprehensive profiling of circular RNAs with nanopore sequencing and CIRI-long. Nat Biotechnol. 2021; 39(7):836-845.

19.Yuanchao Xue, Runsheng Chen*, Lianghu Qu*, Xiaofeng Cao*. Noncoding RNA: from dark matter to bright star. Science China Life sciences. 2020; 63, 463-468.

20. Rong Ye, Changchang Cao, Yuanchao Xue*. Enhancer RNA: biogenesis, function, and regulation. Essays Biochem. 2020; 64(6): 883-894.

21.Yuanchao Xue^#,*, Hao Qian^#, Jing Hu, Bing Zhou, Yu Zhou, Xihao Hu, Aziz Karakhanyan, Zhiping Pang, Xiang-Dong Fu*. Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. Nat Neurosci. 2016; 19(6):807-15.

22. Juan Chen^#, Yuanchao Xue*. Emerging roles of non-coding RNAs in epigenetic regulation. Sci China Life Sci. 2016; 59(3):227-35.

23.Yuanchao Xue, Kunfu Ouyang, Jie Huang, Yu Zhou, Hong Ouyang, Hairi Li, Gang Wang, Qijia Wu, Chaoliang Wei, Yanzhen Bi, Li Jiang, Zhiqiang Cai, Hui Sun, Kang Zhang, Yi Zhang, Ju Chen, Xiang-Dong Fu*. Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell. 2013; 152(1-2):82-96. (Highlight by Nature, 2013, 493: 275; Science, 2013, 339: 374; Nature Reviews Neuroscience, 2013, 14, 155)

24.Yuanchao Xue^#, Yu Zhou^#, Tongbin Wu, Tuo Zhu, Xiong Ji, Young-SooKwon, Chao Zhang, Gene Yeo, Douglas L. Black, Hui Sun, Xiang-Dong Fu*, Yi Zhang*. Genome-wide Analysis of PTB-RNA Interactions Reveals a Strategy Used by the General Splicing Repressor to Modulate Exon Inclusion or Skipping. Mol Cell. 2009; 36(6):996-1006. (Cover story; Preview by Mol Cell, 2009;36(6):918-9)