研究員，複旦大學，生物醫學研究院（2020.1-今）
青年研究員，複旦大學，生物醫學研究院 (2013.9-2019.12)
博士後

，美國斯坦福大學 (2011.6-20013.7)
助理研究員
，癌基因及相關基因國家重點實驗室, 上海市腫瘤研究所(2009.7-2011.6)

 

研究方向

課題組結合腫瘤分子生物學、RNA生物學和生物信息學
，致力於腫瘤診療新靶點的發現和作用研究，建立了相關的RNA測序、生物信息方法和數據庫（exLR-seq, ASJA, EV-origin, exoRBase, RJunBase）
，提出並發現癌症中存在豐富的腫瘤特異轉錄本TSTs (Nat Commun, 2016; Cell Rep, 2018; Hepatology, 2019; Cancer Res, 2020; Nucleic Acids Res, 2021)

；解析了外泌體/細胞外囊泡RNA組分及其在癌症中的應用(Cell Res, 2015; Nucleic Acids Res, 2018&2022; Clin Chem, 2019; Gut, 2020)。課題組目前重點開展腫瘤標誌物和核酸藥物（小核酸和mRNA）研究。

 

工作經曆及學術成就

2009年博士畢業後留在上海市腫瘤研究所癌基因及相關基因國家重點實驗室工作
，2011年至2013年在斯坦福大學醫學院做博士後
，2013年9月起任複旦大學附屬腫瘤醫院/腫瘤研究所和生物醫學研究院PI。致力於RNA表型組學和轉化醫學研究
，近年首次報道環狀RNA選擇性富集於外泌體，並建立首個人類血液外泌體長鏈RNA數據庫exoRBase，發現腫瘤特異轉錄本LIN28B-TST及潛在意義。迄今發表SCI論文60餘篇，H-index 45，被引超過1萬次，申請發明專利三項，獲得國家重點研發課題、國家自然科學基金
、上海市科技創新項目，以及國家“萬人計劃”青年拔尖人才
、上海市浦江和啟明星計劃資助。

 

代表論文

1.Hongyan Lai, Yuchen Li, Hena Zhang, Jia Hu, Jiatao Liao, Ying Su, Qin Li, Bing Chen, Caiping Li, Zhen Wang, Yan Li, Jialei Wang, Zhiqiang Meng^#, Zhaohui Huang^#, Shenglin Huang^#. exoRBase 2.0: an atlas of mRNA, lncRNA and circRNA in extracellular vesicles from human biofluids. Nucleic Acids Research. 2022;50(D1):D118-D128.

2.Li Y, Chen B, Zhao J, Li Q, Chen S, Guo T, Li Y, Lai H, Chen Z, Meng Z, Guo W^#, He X^#, Huang S^#, HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein. Advanced Science. 2021, 2001701.

3.Qin Li, Hongyan Lai, Yuchen Li, Bing Chen, Siyuan Chen, Yan Li, Zhaohui Huang, Zhiqiang Meng, Peng Wang, Zhixiang Hu^#, Shenglin Huang^#. RJunBase: a database of RNA splice junctions in human normal and cancerous tissues. Nucleic Acids Research. 2021;49(D1):D201-D211.

4.Qiupeng Zheng, Jingjing Zhao, Hui Yu, Huajie Zong, Xigan He, Yiming Zhao, Yan Li, Yu Wang, Yichao Bao, Yuchen Li, Bing Chen, Weijie Guo, Yilin Wang, Zhiao Chen, Yingjun Zhao, Lu Wang^#, Xianghuo He^#, Shenglin Huang^#. Tumor-specific Transcripts are Frequently Expressed in Hepatocellular Carcinoma with Clinical Implication and Potential Function. Hepatology. 2020;71(1):259-274.

5.Yu S, Li Y, Liao Z, Wang Z, Wang Z, Li Y, Qian L, Zhao J, Zong H, Kang B, Zou WB, Chen K, He X, Meng Z, Chen Z^#, Huang S^#, Wang P^#. Plasma extracellular vesicle long RNA profiling identifies a diagnostic signature for the detection of pancreatic ductal adenocarcinoma. Gut. 2020;69(3):540-550.

6.Yuchen Li, Jingjing Zhao, Shulin Yu, Zhen Wang, Xigan He, Yonghui Su, Tianan Guo, Haoyue Sheng, Jie Chen, Qiupeng Zheng, Yan Li, Weijie Guo, Xiaohong Cai, Guohai Shi, Jiong Wu, Lu Wang, Peng Wang^#, Xianghuo He^#, Shenglin Huang^#. Extracellular vesicles long RNA sequencing reveals abundant mRNA, circRNA and lncRNA in human blood as biomarkers for cancer diagnosis. Clinical Chemistry. 2019;65(6):798-808.

7.Xiu B, Chi Y, Liu L, Chi W, Zhang Q, Chen J, Guo R, Si J, Li L, Xue J, Shao ZM, Wu ZH^#, Huang S^#, Wu J^#. LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription. Mol Cancer. 2019;18(1):187.

8.Jingjing Zhao, Qin Li, Yuchen Li, Xianghuo He, Qiupeng Zheng^#, Shenglin Huang^#. ASJA: Assembling Splice Junctions Analysis. Computational and Structural Biotechnology Journal. 2019;17:1143-1150.

9.Guo W, Hu Z, Bao Y, Li Y, Li S, Zheng Q, Lyu D, Chen D, Yu T, Li Y, Zhu X, Ding J, Zhao Y, He X^#, Huang S^#. A LIN28B Tumor-Specific Transcript in Cancer. Cell Reports. 2018; 22(8):2016-2025.

10.Shengli Li, Yuchen Li, Bing Chen, Jingjing Zhao, Shulin Yu, Yan Tang, Qiupeng Zheng, Yan Li, Peng Wang, Xianghuo He, Shenglin Huang^#. exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes. Nucleic Acids Research. 2018;46:D106–D112.

11.Qiupeng Zheng, Chunyang Bao, Weijie Guo, Shuyi Li, Jie Chen, Bin Chen, Yanting Luo, Dongbin Lyu, Yan Li, Guohai Shi, Linhui Liang, Jianren Gu, Xianghuo He^#, Shenglin Huang^#. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nature Communications. 2016; 7:11215.

12.Yan Li, Qiupeng Zheng, Chunyang Bao, Shuyi Li, Weijie Guo, Jiang Zhao, Di Chen, Jianren Gu, Xianghuo He^#, Shenglin Huang^#. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Research. 2015;25(8):981-4.